Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00220 ...
Drug Name Nelfinavir
Molecular Weight 567.782
Molecular Formula C32H45N3O4S
CAS Number 159989-64-7
SMILES [H][C@@]12CCCC[C@]1([H])CN(C[C@@H](O)[C@H](CSC1=CC=CC=C1)NC(=O)C1=C(C)C(O)=CC=C1)[C@@H](C2)C(=O)NC(C)(C)C
External Links
DRUGBANK DB00220
PubChem Compound 64143
PDR 1821
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 6.0 - 6.0 - DRUGBANK
Melting Point 349.84 ℃ 349.84 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 50.0 % 20-80 % PO, oral; food; AIDS,HIV; The Pharmacological Basis of Therapeutics
C Max 3200.0 ng/ml 3.2±1.2 mcg/ml adults; AIDS,HIV; The Pharmacological Basis of Therapeutics
T Max 3.0 h 3.0±1.1 h adults; AIDS,HIV; The Pharmacological Basis of Therapeutics
Clearance 0.72 L/h/kg 12.0±7.2 ml/min/kg apparent clearance; normal,healthy; patients; Children ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 4.5 L/kg 2.0-7 L/kg DRUGBANK
Volume of Distribution 4.5 L/kg 2-7 L/kg Apparent volume of distribution; normal,healthy; patients; The Pharmacological Basis of Therapeutics
Half-life 4.3 h 3.5-5 h DRUGBANK
Half-life 4.0 h 3-5 h PO, oral; The Pharmacological Basis of Therapeutics
Toxicity LD50 5000.0 mg/kg >5 g/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 87.0 % 87 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 1.5 % 1-2 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 22.0 % 22 % Faeces excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 1.5 % 1-2 % Urinary excretion; normal,healthy; AIDS,HIV; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 98.0 % 98 % DRUGBANK
Protein Binding 98.5 % 98-99 % normal,healthy; AIDS,HIV; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 110.0 mg/kg/day 110 mg/kg/day PO, oral Viracept nelfinavir mesylate PDR
Max dose for children 2500.0 mg/day 2500 mg/day PO, oral Viracept nelfinavir mesylate PDR
Max dose for adolescents 2500.0 mg/day 2500 mg/day PO, oral Viracept nelfinavir mesylate PDR
Max dose for adults 2500.0 mg/day 2500 mg/day PO, oral Viracept nelfinavir mesylate PDR
Max dose for geriatric 2500.0 mg/day 2500 mg/day PO, oral Viracept nelfinavir mesylate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1