DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD00209
Drug Name	Trospium
Molecular Weight	392.518
Molecular Formula	C25H30NO3
CAS Number	47608-32-2
SMILES	[H][C@]12CC[C@]([H])(C[C@@H](C1)OC(=O)C(O)(C1=CC=CC=C1)C1=CC=CC=C1)[N+]21CCCC1
External Links
	DRUGBANK	DB00209
	PubChem Compound	5284632
	PDR	23958
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Absorption	9.6	%	9.6	%		DRUGBANK
Clearance	29.1	L/h	29.07	L/h	Renal clearance;	DRUGBANK
Clearance	0.83	L/h/kg	13.9	ml/min/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	395.0	L	395±140	L		DRUGBANK
Volume of Distribution	5.1	L/kg	5.1	L/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Half-life	20.0	h	20	h		DRUGBANK
Half-life	5.0	h	5	h	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Eliminate Route	85.2	%	85.2	%	Faeces excretion; PO, oral;	DRUGBANK
Eliminate Route	5.8	%	5.8	%	Urinary excretion; PO, oral;	DRUGBANK
Eliminate Route	60.0	%	60	%	Urinary excretion; Unchanged drug;	DRUGBANK
Protein Binding	67.5	%	50-85	%		DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	60.0	mg/day	60	mg/day	PO, oral	Trospium Chloride Tablets	trospium chloride	PDR
Max dose for elderly	60.0	mg/day	60	mg/day	PO, oral	Trospium Chloride Tablets	trospium chloride	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1