Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00207 ...
Drug Name Azithromycin
Molecular Weight 748.9845
Molecular Formula C38H72N2O12
CAS Number 83905-01-5
SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O
External Links
DRUGBANK DB00207
PubChem Compound 447043
PDR 1012
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.03 - 3.03 - http://www.medicines.org.au/files/afpazith.pdf
Melting Point 126.0 ℃ 126 ℃ http://www.chemspider.com/Chemical-Structure.2298410.html
pKa 8.5 - 8.5 - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174372

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 37.0 % 37.0 % PO, oral; food; food → ; DRUGBANK
Bioavailability 34.0 % 34±19 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 400.0 ng/ml 0.4 mcg/ml PO, oral; adults; patients; The Pharmacological Basis of Therapeutics
T Max 2.5 h 2-3 h PO, oral; adults; patients; The Pharmacological Basis of Therapeutics
Clearance 37.8 L/h 630.0 ml/min Plasma clearance; PO, oral; intravenous injection, IV; DRUGBANK
Clearance 0.54 L/h/kg 9.0 ml/min/kg The Pharmacological Basis of Therapeutics
Clearance 0.60 L/h/kg 10 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 31.1 L/kg 31.1 L/kg Steady state volume of distribution; PO, oral; DRUGBANK
Volume of Distribution 31.0 L/kg 31.0 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 33.0 L/kg 33 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 68.0 h 68 h elimination half-life; DRUGBANK
Half-life 40.0 h 40.0 h Hepatic cirrhosis, cirr → ; The Pharmacological Basis of Therapeutics
Half-life 68.0 h 68±8 h terminal half-life; The Pharmacological Basis of Therapeutics
Half-life 69.0 h 69 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2000.0 mg/kg >2000 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 6.0 % ~6 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 12.0 % 12 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 51.0 % 51 % human, homo sapiens; DRUGBANK
Protein Binding 7.0 % 7 % human, homo sapiens; DRUGBANK
Protein Binding 28.5 % 7-50 % The Pharmacological Basis of Therapeutics
Protein Binding 50.0 % 50 % The Pharmacological Basis of Therapeutics
Protein Binding 12.0 % 12 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 20.0 mg/kg/day 20 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for infants 10.0 mg/kg/day 10 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for infants 30.0 mg/kg 30 mg/kg PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for infants 20.0 mg/kg/day 20 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for infants 60.0 mg/kg 60 mg/kg PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for infants 10.0 mg/kg/day 10 mg/kg/day Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for infants 20.0 mg/kg/day 20 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for infants 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for infants 20.0 mg/kg/day 20 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 12.0 mg/kg/day 12 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 30.0 mg/kg 30 mg/kg PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 20.0 mg/kg/day 20 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 60.0 mg/kg 60 mg/kg PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 10.0 mg/kg/day 10 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 30.0 mg/kg 30 mg/kg PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 20.0 mg/kg/day 20 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 60.0 mg/kg 60 mg/kg PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 500.0 mg/dose 500 mg/dose PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 1500.0 mg/dose 1.5 g/dose PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 1000.0 mg/day 1000 mg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 2000.0 mg/dose 2 g/dose PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for children 500.0 mg/dose 500 mg/dose intravenous injection, IV Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 500.0 mg/day 500 mg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 1200.0 mg/day 1200 mg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 2000.0 mg/dose 2 g/dose PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 500.0 mg/day 500 mg/day intravenous infusion, iv in drop Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 12.0 mg/kg/day 12 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 30.0 mg/kg/dose 30 mg/kg/dose PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 20.0 mg/kg/day 20 mg/kg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 1200.0 mg/kg 1200 mg/kg PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 60.0 mg/kg 60 mg/kg PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 500.0 mg/dose 500 mg/dose PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 1500.0 mg/dose 1.5 g/dose PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 1000.0 mg/day 1000 mg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 2000.0 mg/dose 2 g/dose PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adolescents 500.0 mg/dose 500 mg/dose intravenous injection, IV Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adults 500.0 mg/day 500 mg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adults 1200.0 mg/day 1200 mg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adults 2000.0 mg/dose 2 g/dose PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for adults 500.0 mg/day 500 mg/day intravenous infusion, iv in drop Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for geriatric 500.0 mg/day 500 mg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for geriatric 1200.0 mg/day 1200 mg/day PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for geriatric 2.0 g/dose 2 g/dose PO, oral Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR
Max dose for geriatric 500.0 mg/day 500 mg/day intravenous infusion, iv in drop Zithromax 250 mg and 500 mg Tablets and Oral Suspension azithromycin PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1