Basic Information
| Drug ID | DDPD00205 |
|
| Drug Name | Pyrimethamine | |
| Molecular Weight | 248.711 | |
| Molecular Formula | C12H13ClN4 | |
| CAS Number | 58-14-0 | |
| SMILES | CCC1=C(C(N)=NC(N)=N1)C1=CC=C(Cl)C=C1 | |
| External Links | ||
| DRUGBANK | DB00205 | |
| T3DB | T3D4779 | |
| PubChem Compound | 4993 | |
| PDR | 2210 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.69 | - | 2.69 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 233.5 | ℃ | 233.5 | ℃ | PhysProp |
| Water Solubility | 121.0 | mg/L | 121 | mg/L | DRUGBANK |
| pKa | 7.34 | - | 7.34 | - | PERRIN,DD (1972) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 4.0 | h | 2-6 | h | DRUGBANK | |
| Clearance | 0.003120 | L/h/kg | 0.052 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.43 | L/kg | 0.43 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 96.0 | h | 96 | h | DRUGBANK | Half-life | 140.0 | h | 140 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 87.0 | % | 87 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 1.0 | mg/kg/day | 1 | mg/kg/day | Daraprim | pyrimethamine | PDR | |
| Max dose for neonates | 2.0 | mg/kg/day | 2 | mg/kg/day | Daraprim | pyrimethamine | PDR | |
| Max dose for infants | 1.0 | mg/kg/day | 1 | mg/kg/day | Daraprim | pyrimethamine | PDR | |
| Max dose for infants | 2.0 | mg/kg/day | 2 | mg/kg/day | Daraprim | pyrimethamine | PDR | |
| Max dose for children | 1.0 | mg/kg/day | 1 | mg/kg/day | Daraprim | pyrimethamine | PDR | |
| Max dose for children | 2.0 | mg/kg/day | 2 | mg/kg/day | Daraprim | pyrimethamine | PDR | |
| Max dose for children | 50.0 | mg/day | 50 | mg/day | Daraprim | pyrimethamine | PDR | |
| Max dose for adolescents | 75.0 | mg/day | 75 | mg/day | PO, oral | Daraprim | pyrimethamine | PDR |
| Max dose for adults | 75.0 | mg/day | 75 | mg/day | PO, oral | Daraprim | pyrimethamine | PDR |
| Max dose for geriatric | 75.0 | mg/day | 75 | mg/day | PO, oral | Daraprim | pyrimethamine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1