Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00204 ...
Drug Name Dofetilide
Molecular Weight 441.565
Molecular Formula C19H27N3O5S2
CAS Number 115256-11-6
SMILES CN(CCOC1=CC=C(NS(C)(=O)=O)C=C1)CCC1=CC=C(NS(C)(=O)=O)C=C1
External Links
DRUGBANK DB00204
PubChem Compound 71329
PDR 1857
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.1 - 2.1 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 90.0 % >90 % food ↓ ; DRUGBANK
Bioavailability 96.0 % 96(83-108) % PO, oral; The Pharmacological Basis of Therapeutics
C Max 2.3 ng/ml 2.3±1.1 ng/ml Oral single dose; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.8 h 1-2.5 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 0.31 L/h/kg 5.23±0.30 ml/min/kg hydrolysis; normal,healthy; adults; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.31 L/h/kg 5.2 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 3.0 L/kg 3.0 L/kg DRUGBANK
Volume of Distribution 3.4 L/kg 3.44±0.25 L/kg hydrolysis; normal,healthy; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.3 L/kg 3.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 10.0 h 10 h DRUGBANK
Half-life 7.5 h 7.5±0.4 h normal,healthy; Male, men;  Female, women; RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Half-life 8.1 h 8.1 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 52.0 % 52±2 % Urinary excretion; adults; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 65.0 % 60-70 % DRUGBANK
Protein Binding 60.0 % 64 % Male, men; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 1.0 mg/day 1000 mcg/day PO, oral Tikosyn dofetilide PDR
Max dose for elderly 1.0 mg/day 1000 mcg/day PO, oral Tikosyn dofetilide PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1