DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD00199
Drug Name	Erythromycin
Molecular Weight	733.9268
Molecular Formula	C37H67NO13
CAS Number	114-07-8
SMILES	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
External Links
	DRUGBANK	DB00199
	T3DB	T3D4764
	PubChem Compound	12560
	PDR	1071
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	2.6	-	2.6	-	http://www.t3db.ca/toxins/T3D4764
Boiling Point	719.69	℃	719.69	℃	https://www.chemicalbook.com/ChemicalProductProperty_US_CB8300078.aspx
Melting Point	189.5	℃	133-135	℃	https://www.chemicalbook.com/ChemicalProductProperty_US_CB8300078.aspx
Water Solubility	2000.0	mg/L	2	mg/ml	https://www.chemicalbook.com/ChemicalProductProperty_US_CB8300078.aspx
pKa	8.88	-	8.88	-	https://www.chemicalbook.com/ChemicalProductProperty_US_CB8300078.aspx
Log S	-3.2	-	-3.2	-	http://www.t3db.ca/toxins/T3D4764

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
AUC	7300.0	ng.h/ml	7.3±3.9	mg.h/l	PO, oral;		DRUGBANK
Bioavailability	31.5	%	18-45	%	PO, oral;		DRUGBANK
Bioavailability	35.0	%	35±25	%			The Pharmacological Basis of Therapeutics
C Max	1.8	ng/ml	1.8	mcg/L	PO, oral;		DRUGBANK
C Max	2200.0	ng/ml	0.9-3.5	mcg/ml	PO, oral; extended release formulation;		The Pharmacological Basis of Therapeutics
C Max	950.0	ng/ml	0.5-1.4	mcg/ml	Tablet, PO, oral;		The Pharmacological Basis of Therapeutics
T Max	1.2	h	1.2	h	PO, oral;		DRUGBANK
T Max	3.0	h	2.1-3.9	h	PO, oral; extended release formulation;		The Pharmacological Basis of Therapeutics
T Max	2.5	h	2-3	h	Tablet, PO, oral;		The Pharmacological Basis of Therapeutics
Clearance	0.53	L/h/kg	0.53±0.13	l/h/kg	intravenous injection, IV; normal,healthy;		DRUGBANK
Clearance	42.2	L/h	42.2±10.1	L/h	Hepatitis, Hep; patients;	Hepatitis, Hep ↓ ;	DRUGBANK
Clearance	113.2	L/h	113.2±44.2	L/h	normal,healthy; patients;		DRUGBANK
Clearance	0.55	L/h/kg	9.1±4.1	ml/min/kg	hydrolysis;	RD, renal impairment, Renal disease，including uremia → ;	The Pharmacological Basis of Therapeutics
Clearance	0.34	L/h/kg	5.6	ml/min/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	0.78	L/kg	0.78±0.44	L/kg		RD, renal impairment, Renal disease，including uremia ↑ ;	The Pharmacological Basis of Therapeutics
Volume of Distribution	0.95	L/kg	0.95	L/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Half-life	3.5	h	3.5	h	elimination half-life; PO, oral; different study;		DRUGBANK
Half-life	2.8	h	2.4-3.1	h	elimination half-life; PO, oral; different study;		DRUGBANK
Half-life	1.6	h	1.6±0.7	h		Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia → ;	The Pharmacological Basis of Therapeutics
Half-life	2.0	h	2	h	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Toxicity LD50	9272.0	mg/kg	9272.0	mg/kg	PO, oral; Rattus, Rat;		DRUGBANK
Eliminate Route	5.0	%	<5	%	Urinary excretion; PO, oral;		DRUGBANK
Eliminate Route	12.0	%	12±7	%	Urinary excretion; Unchanged drug;		The Pharmacological Basis of Therapeutics
Protein Binding	85.0	%	80-90	%			DRUGBANK
Protein Binding	84.0	%	84±3	%		RD, renal impairment, Renal disease，including uremia → ;	The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for neonates	50.0	mg/kg/day	50	mg/kg/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for neonates	40.0	mg/kg/day	40	mg/kg/day	intravenous injection, IV	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for infants	50.0	mg/kg/day	50	mg/kg/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for infants	100.0	mg/kg/day	100	mg/kg/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for infants	20.0	mg/kg/day	20	mg/kg/day	intravenous injection, IV	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for infants	40.0	mg/kg/day	40	mg/kg/day	intravenous injection, IV	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for children	50.0	mg/kg/day	50	mg/kg/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for children	100.0	mg/kg/day	100	mg/kg/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for children	20.0	mg/kg/day	20	mg/kg/day	intravenous injection, IV	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for children	40.0	mg/kg/day	40	mg/kg/day	intravenous injection, IV	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for children	2000.0	mg/day	2	g/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for children	4000.0	mg/day	4	g/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for children	4000.0	mg/day	4	g/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for children	4000.0	mg/day	4	g/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for adolescents	50.0	mg/kg/day	50	mg/kg/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for adolescents	100.0	mg/kg/day	100	mg/kg/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for adolescents	20.0	mg/kg/day	20	mg/kg/day	intravenous injection, IV	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for adolescents	40.0	mg/kg/day	40	mg/kg/day	intravenous injection, IV	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for adolescents	2000.0	mg/day	2	g/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for adolescents	4000.0	mg/day	4	g/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for adolescents	4000.0	mg/day	4	g/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for adolescents	4000.0	mg/day	4	g/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for adults	4000.0	mg/day	4	g/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for adults	4000.0	mg/day	4	g/day	intravenous injection, IV	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for geriatric	4000.0	mg/day	4	g/day	PO, oral	Erythrocin Stearate	erythromycin stearate	PDR
Max dose for geriatric	4000.0	mg/day	4	g/day	intravenous injection, IV	Erythrocin Stearate	erythromycin stearate	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1