Basic Information

Drug ID DDPD00199 ...
Drug Name Erythromycin
Molecular Weight 733.9268
Molecular Formula C37H67NO13
CAS Number 114-07-8
SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
External Links
DRUGBANK DB00199
T3DB T3D4764
PubChem Compound 12560
PDR 1071
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.6 - 2.6 - http://www.t3db.ca/toxins/T3D4764
Boiling Point 719.69 719.69 https://www.chemicalbook.com/ChemicalProductProperty_US_CB8300078.aspx
Melting Point 189.5 133-135 https://www.chemicalbook.com/ChemicalProductProperty_US_CB8300078.aspx
Water Solubility 2000.0 mg/L 2 mg/ml https://www.chemicalbook.com/ChemicalProductProperty_US_CB8300078.aspx
pKa 8.88 - 8.88 - https://www.chemicalbook.com/ChemicalProductProperty_US_CB8300078.aspx
Log S -3.2 - -3.2 - http://www.t3db.ca/toxins/T3D4764

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 7300.0 ng.h/ml 7.3±3.9 mg.h/l PO, oral; DRUGBANK
Bioavailability 31.5 % 18-45 % PO, oral; DRUGBANK
Bioavailability 35.0 % 35±25 % The Pharmacological Basis of Therapeutics
C Max 1.8 ng/ml 1.8 mcg/L PO, oral; DRUGBANK
C Max 2200.0 ng/ml 0.9-3.5 mcg/ml PO, oral; extended release formulation; The Pharmacological Basis of Therapeutics
C Max 950.0 ng/ml 0.5-1.4 mcg/ml Tablet, PO, oral; The Pharmacological Basis of Therapeutics
T Max 1.2 h 1.2 h PO, oral; DRUGBANK
T Max 3.0 h 2.1-3.9 h PO, oral; extended release formulation; The Pharmacological Basis of Therapeutics
T Max 2.5 h 2-3 h Tablet, PO, oral; The Pharmacological Basis of Therapeutics
Clearance 0.53 L/h/kg 0.53±0.13 l/h/kg intravenous injection, IV; normal,healthy; DRUGBANK
Clearance 42.2 L/h 42.2±10.1 L/h Hepatitis, Hep; patients; Hepatitis, Hep ↓ ; DRUGBANK
Clearance 113.2 L/h 113.2±44.2 L/h normal,healthy; patients; DRUGBANK
Clearance 0.55 L/h/kg 9.1±4.1 ml/min/kg hydrolysis; RD, renal impairment, Renal disease,including uremia → ; The Pharmacological Basis of Therapeutics
Clearance 0.34 L/h/kg 5.6 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.78 L/kg 0.78±0.44 L/kg RD, renal impairment, Renal disease,including uremia ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.95 L/kg 0.95 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 3.5 h 3.5 h elimination half-life; PO, oral; different study; DRUGBANK
Half-life 2.8 h 2.4-3.1 h elimination half-life; PO, oral; different study; DRUGBANK
Half-life 1.6 h 1.6±0.7 h Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease,including uremia → ; The Pharmacological Basis of Therapeutics
Half-life 2.0 h 2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 9272.0 mg/kg 9272.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 5.0 % <5 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 12.0 % 12±7 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 85.0 % 80-90 % DRUGBANK
Protein Binding 84.0 % 84±3 % RD, renal impairment, Renal disease,including uremia → ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 50.0 mg/kg/day 50 mg/kg/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for neonates 40.0 mg/kg/day 40 mg/kg/day intravenous injection, IV Erythrocin Stearate erythromycin stearate PDR
Max dose for infants 50.0 mg/kg/day 50 mg/kg/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for infants 100.0 mg/kg/day 100 mg/kg/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for infants 20.0 mg/kg/day 20 mg/kg/day intravenous injection, IV Erythrocin Stearate erythromycin stearate PDR
Max dose for infants 40.0 mg/kg/day 40 mg/kg/day intravenous injection, IV Erythrocin Stearate erythromycin stearate PDR
Max dose for children 50.0 mg/kg/day 50 mg/kg/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for children 100.0 mg/kg/day 100 mg/kg/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for children 20.0 mg/kg/day 20 mg/kg/day intravenous injection, IV Erythrocin Stearate erythromycin stearate PDR
Max dose for children 40.0 mg/kg/day 40 mg/kg/day intravenous injection, IV Erythrocin Stearate erythromycin stearate PDR
Max dose for children 2000.0 mg/day 2 g/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for children 4000.0 mg/day 4 g/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for children 4000.0 mg/day 4 g/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for children 4000.0 mg/day 4 g/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for adolescents 50.0 mg/kg/day 50 mg/kg/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for adolescents 100.0 mg/kg/day 100 mg/kg/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for adolescents 20.0 mg/kg/day 20 mg/kg/day intravenous injection, IV Erythrocin Stearate erythromycin stearate PDR
Max dose for adolescents 40.0 mg/kg/day 40 mg/kg/day intravenous injection, IV Erythrocin Stearate erythromycin stearate PDR
Max dose for adolescents 2000.0 mg/day 2 g/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for adolescents 4000.0 mg/day 4 g/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for adolescents 4000.0 mg/day 4 g/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for adolescents 4000.0 mg/day 4 g/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for adults 4000.0 mg/day 4 g/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for adults 4000.0 mg/day 4 g/day intravenous injection, IV Erythrocin Stearate erythromycin stearate PDR
Max dose for geriatric 4000.0 mg/day 4 g/day PO, oral Erythrocin Stearate erythromycin stearate PDR
Max dose for geriatric 4000.0 mg/day 4 g/day intravenous injection, IV Erythrocin Stearate erythromycin stearate PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1