Basic Information
| Drug ID | DDPD00198 |
|
| Drug Name | Oseltamivir | |
| Molecular Weight | 312.4045 | |
| Molecular Formula | C16H28N2O4 | |
| CAS Number | 196618-13-0 | |
| SMILES | CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 | |
| External Links | ||
| DRUGBANK | DB00198 | |
| PubChem Compound | 65028 | |
| PDR | 2099 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.0 | - | 1.0 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| AUC | 112.0 | ng.h/ml | 112.0 | ng.h/ml | Capsule, PO, Oral; food; | food → ; | DRUGBANK | AUC | 2719.0 | ng.h/ml | 2719.0 | ng.h/ml | Capsule, PO, Oral; food; Active metabolite; | food → ; | DRUGBANK |
| Bioavailability | 75.0 | % | >75 | % | PO, oral; | DRUGBANK | |
| C Max | 65.0 | ng/ml | 65.0 | ng/ml | Capsule, PO, Oral; food; | food → ; | DRUGBANK | C Max | 348.0 | ng/ml | 348.0 | ng/ml | Capsule, PO, Oral; food; Active metabolite; | food → ; | DRUGBANK |
| Clearance | 18.8 | L/h | 18.8 | L/h | Renal clearance; | DRUGBANK | |
| Volume of Distribution | 24.5 | L | ~23-26 | L | Average volume of distribution; human, homo sapiens; | DRUGBANK | |
| Half-life | 2.0 | h | 1-3 | h | PO, oral; | DRUGBANK | Half-life | 8.0 | h | 6-10 | h | PO, oral; | DRUGBANK |
| Eliminate Route | 20.0 | % | <20 | % | Faeces excretion; PO, oral; | DRUGBANK | |
| Protein Binding | 42.0 | % | 42 | % | plasma proteins; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 6.0 | mg/kg/day | 3 | mg/kg/dose | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for neonates | 6.0 | mg/kg/day | 3 | mg/kg/dose | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for neonates | 6.0 | mg/kg/day | 3 | mg/kg/dose | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for neonates | 3.0 | mg/kg/day | 1.5 | mg/kg/dose | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for neonates | 2.0 | mg/kg/day | 1 | mg/kg/dose | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for infants | 6.0 | mg/kg/day | 3 | mg/kg/dose | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for infants | 7.0 | mg/kg/day | 3.5 | mg/kg/dose | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for infants | 6.0 | mg/kg/day | 3 | mg/kg/dose | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for children | 75.0 | mg | 75 | mg | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for children | 60.0 | mg | 60 | mg | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for children | 45.0 | mg | 45 | mg | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for children | 30.0 | mg | 30 | mg | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for adolescents | 75.0 | mg | 75 | mg | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for adults | 75.0 | mg | 75 | mg | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Tamiflu | oseltamivir phosphate | PDR | |
| Max dose for geriatric | 75.0 | mg | 75 | mg | PO, oral | bid | Tamiflu | oseltamivir phosphate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1