Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00193 ...
Drug Name Tramadol
Molecular Weight 263.3752
Molecular Formula C16H25NO2
CAS Number 27203-92-5
SMILES COC1=CC=CC(=C1)[C@@]1(O)CCCC[C@@H]1CN(C)C
External Links
DRUGBANK DB00193
T3DB T3D2575
PubChem Compound 33741
PDR 2699
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.34 - 1.34 - 'MSDS'
Boiling Point 406.6 ℃ 406.6 ℃ Chemical Book
Melting Point 179.5 ℃ 178-181 ℃ 'MSDS'
pKa 9.41 - 9.41 - 'FDA label'

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % ~100 % PO, oral; DRUGBANK
Absorption 100.0 % ~100 % IM,intramuscular injection; DRUGBANK
Bioavailability 75.0 % 75.0 % PO, oral; DRUGBANK
Bioavailability 77.0 % 77.0 % Rectal Administration; DRUGBANK
Bioavailability 72.5 % 70-75 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 300.0 ng/ml 300.0 ug/L Oral single dose; DRUGBANK
C Max 348.0 ng/ml 348.0 ug/L Oral multiple dose; DRUGBANK
C Max 166.0 ng/ml 166.0 ug/L IM,intramuscular injection; DRUGBANK
C Max 294.0 ng/ml 294.0 ug/L Rectal Administration; DRUGBANK
C Max 592.0 ng/ml 592±178 ng/ml Tablet, PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
C Max 110.0 ng/ml 110±32 ng/ml Tablet, PO, oral; Active metabolite; immediate release formulation; The Pharmacological Basis of Therapeutics
T Max 2.5 h 2-3 h PO, oral; DRUGBANK
T Max 1.8 h 1.6-1.9 h Oral single dose; DRUGBANK
T Max 0.75 h 0.75 h IM,intramuscular injection; DRUGBANK
T Max 3.3 h 3.3 h Rectal Administration; DRUGBANK
T Max 2.3 h 2.3±1.4 h Tablet, PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
T Max 2.4 h 2.4±1.1 h Tablet, PO, oral; Active metabolite; immediate release formulation; The Pharmacological Basis of Therapeutics
Tss 48.0 h 2.0 day Oral single dose; DRUGBANK
Metabolic 92.5 % 90-95 % Liver metabolism; Caucasian; DRUGBANK
Metabolic 7.5 % 5-10 % Liver metabolism; poor metabolizers, PM; DRUGBANK
Clearance 0.22 L/h/kg 3.73 ml/min/kg RD, renal impairment, Renal disease，including uremia; patients; DRUGBANK
Clearance 0.51 L/h/kg 8.5 ml/min/kg normal,healthy; adults; DRUGBANK
Clearance 0.48 L/h/kg 8(6-12) ml/min/kg hepatopathy，LD ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.39 L/h/kg 6.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 2.8 L/kg 2.6-2.9 L/kg DRUGBANK
Volume of Distribution 306.0 L 306.0 L Total volume of distribution; PO, oral; DRUGBANK
Volume of Distribution 203.0 L 203.0 L Total volume of distribution; parenteral administration; DRUGBANK
Volume of Distribution 2.7 L/kg 2.7(2.3-3.9) L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 2.8 L/kg 2.8 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 5.5 h 5-6 h DRUGBANK
Half-life 8.0 h 8 h Metabolite; DRUGBANK
Half-life 5.5 h 5.5(4.5-7.5) h RD, renal impairment, Renal disease，including uremia ↑ ;chronic liver disease ↑ ; The Pharmacological Basis of Therapeutics
Half-life 5.8 h 5.8 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 350.0 mg/kg 350.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 325.0 mg/kg 300-350 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 30.0 % ~30 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 20.0 % 10-30 % Urinary excretion; PO, oral; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 20.0 % ~20 % plasma proteins; DRUGBANK
Protein Binding 20.0 % 20 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 0.0 0 Ultram ER tramadol hydrochloride PDR
Max dose for children 0.0 0 Ultram ER tramadol hydrochloride PDR
Max dose for adolescents 400.0 mg/day 400 mg/day Tablet,PO，oral Ultram ER tramadol hydrochloride PDR
Max dose for adolescents 300.0 mg/day 300 mg/day Tablet,PO，oral Ultram ER tramadol hydrochloride PDR
Max dose for adolescents 300.0 mg/day 300 mg/day Tablet,PO，oral Ultram ER tramadol hydrochloride PDR
Max dose for adults 400.0 mg/day 400 mg/day Tablet,PO，oral Ultram ER tramadol hydrochloride PDR
Max dose for adults 300.0 mg/day 300 mg/day PO, oral Ultram ER tramadol hydrochloride PDR
Max dose for geriatric 400.0 mg/day 400 mg/day Tablet,PO，oral Ultram ER tramadol hydrochloride PDR
Max dose for geriatric 300.0 mg 300 mg PO, oral Ultram ER tramadol hydrochloride PDR
Max dose for geriatric 300.0 mg/day 300 mg/day PO, oral Ultram ER tramadol hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1