Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00190 ...
Drug Name Carbidopa
Molecular Weight 226.2292
Molecular Formula C10H14N2O4
CAS Number 28860-95-9
SMILES C[C@@](CC1=CC(O)=C(O)C=C1)(NN)C(O)=O
External Links
DRUGBANK DB00190
PubChem Compound 34359
PDR 893
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -1.9 - -1.9 - Kirk K., Yoshida S., and Haufe G. Fluorine and Health. (2008)
Melting Point 205.5 ℃ 203-208 ℃ 'MSDS'
Water Solubility 3.8 mg/L 3.8 mg/L 'MSDS'
pKa 2.3 - 2.3 - Konduru N. and Madhuri G. (2014). IJPSR. Vol. 5

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 55.0 % 40-70 % PO, oral; DRUGBANK
AUC 321.3 ng.h/ml 19.28 mcg.min/ml PO, oral; DRUGBANK
Bioavailability 58.0 % 58.0 % PO, oral; DRUGBANK
C Max 85.0 ng/ml 0.085 mcg/ml PO, oral; DRUGBANK
C Max 165.0 ng/ml 165±77 ng/ml PO, oral; Drug form; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 81.0 ng/ml 81±28 ng/ml PO, oral; Drug form; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 2.4 h 143 min PO, oral; DRUGBANK
T Max 2.1 h 2.1±1.0 h PO, oral; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 51.7 L/h 51.7 L/h DRUGBANK
Clearance 1.1 L/h/kg 18±7 ml/min/kg normal,healthy; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.6 L/kg 3.6 L/kg DRUGBANK
Half-life 1.8 h ~107 min DRUGBANK
Half-life 2.0 h ~2 h normal,healthy; adults; The Pharmacological Basis of Therapeutics
Toxicity LD50 4810.0 mg/kg 4810.0 mg/kg Rattus, Rat; DRUGBANK
Eliminate Route 50.0 % 50 % Urinary excretion; human, homo sapiens; DRUGBANK
Eliminate Route 5.3 % 5.3±2.1 % Urinary excretion; adults; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 76.0 % 76 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 200.0 mg/day 200 mg/day PO, oral Lodosyn carbidopa PDR
Max dose for elderly 200.0 mg/day 200 mg/day PO, oral Lodosyn carbidopa PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1