Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00188 ...
Drug Name Bortezomib
Molecular Weight 384.237
Molecular Formula C19H25BN4O4
CAS Number 179324-69-7
SMILES CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=CN=CC=N1)B(O)O
External Links
DRUGBANK DB00188
PubChem Compound 387447
PDR 407
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 141.0 ℃ 139-143 ℃ Thermo Fisher Scientific Bortezomib Safety Data Sheet
Water Solubility 3550.0 mg/L 3.3-3.8 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
C Max 57.0 ng/ml 57.0 ng/ml intravenous injection, IV; DRUGBANK
C Max 112.0 ng/ml 112.0 ng/ml intravenous injection, IV; DRUGBANK
C Max 86.5 ng/ml 67-106 ng/ml intravenous injection, IV; DRUGBANK
C Max 104.5 ng/ml 89-120 ng/ml intravenous injection, IV; DRUGBANK
Clearance 102.0 L/h 102.0 L/h Average clearance; DRUGBANK
Clearance 112.0 L/h 112.0 L/h Average clearance; DRUGBANK
Clearance 15.0 L/h 15.0 L/h Average clearance; DRUGBANK
Clearance 32.0 L/h 32.0 L/h Average clearance; DRUGBANK
Clearance 1.1 L/h/kg 19 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1191.0 L/m2 498-1884 L/m2 Average volume of distribution; multiple myeloma; patients; DRUGBANK
Volume of Distribution 10.0 L/kg 10 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 116.5 h 40-193 h elimination half-life; Multiple dose; DRUGBANK
Half-life 92.0 h 76-108 h Multiple dose; DRUGBANK
Half-life 18.0 h 18 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity TDLo 0.36 mg/kg/day 5.0 mg/kg/14D mouse; DRUGBANK
Toxicity TDLo 0.13 mg/kg/day 1.6 mg/kg/12D mouse; DRUGBANK
Protein Binding 83.0 % ~83 % plasma proteins; human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 1.3 mg/m2/dose 1.3 mg/m2/dose intravenous injection, IV;subcutaneous injection, SC; Velcade bortezomib PDR
Max dose for adults 1.6 mg/m2/dose 1.6 mg/m2/dose intravenous injection, IV Velcade bortezomib PDR
Max dose for geriatric 1.3 mg/m2/dose 1.3 mg/m2/dose intravenous injection, IV;subcutaneous injection, SC; Velcade bortezomib PDR
Max dose for geriatric 1.6 mg/m2/dose 1.6 mg/m2/dose intravenous injection, IV Velcade bortezomib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1