Basic Information
| Drug ID | DDPD00187 |
|
| Drug Name | Esmolol | |
| Molecular Weight | 295.374 | |
| Molecular Formula | C16H25NO4 | |
| CAS Number | 81147-92-4 | |
| SMILES | COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 | |
| External Links | ||
| DRUGBANK | DB00187 | |
| PubChem Compound | 59768 | |
| PDR | 1159 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.7 | - | 1.7 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Css | 0.18 | mg/kg/mm | 0.05-0.3 | mg/kg/mm | DRUGBANK | |
| Tss | 0.0833 | h | 5.0 | min | DRUGBANK | |
| Clearance | 20.0 | L/h/kg | 20.0 | L/kg/h | Male, men; | DRUGBANK | Clearance | 17.4 | L/h/kg | 290 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.2 | L/kg | 1.2 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.0333 | h | ~2 | min | rapid distribution half-life; | DRUGBANK | Half-life | 0.15 | h | ~9 | min | elimination half-life; | DRUGBANK | Half-life | 3.7 | h | ~3.7 | h | elimination half-life; Metabolite; | DRUGBANK | Half-life | 0.15 | h | 0.15 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 2.0 | % | <2 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 55.0 | % | 55 | % | plasma proteins; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 500.0 | mcg/kg/dose | 500 | mcg/kg/dose | intravenous injection, IV | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for neonates | 720.0 | mg/kg/day | 500 | mcg/kg/minute | intravenous infusion, iv in drop | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for infants | 1.0 | mg/kg/dose | 1000 | mcg/kg/dose | intravenous injection, IV | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for infants | 1440.0 | mg/kg/day | 1000 | mcg/kg/min | intravenous infusion, iv in drop | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for children | 1.0 | mg/kg/dose | 1000 | mcg/kg/dose | intravenous injection, IV | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for children | 1440.0 | mg/kg/day | 1000 | mcg/kg/minute | intravenous infusion, iv in drop | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for adolescents | 1.0 | mg/kg/dose | 1000 | mcg/kg/dose | intravenous injection, IV | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for adolescents | 1440.0 | mg/kg/day | 1000 | mcg/kg/minute | intravenous infusion, iv in drop | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for adults | 500.0 | mcg/kg/dose | 500 | mcg/kg/dose | intravenous injection, IV | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for adults | 288.0 | mg/kg/day | 200 | mcg/kg/min | intravenous infusion, iv in drop | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for adults | 432.0 | mg/kg/day | 300 | mcg/kg/min | intravenous infusion, iv in drop | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for geriatric | 500.0 | mcg/kg/dose | 500 | mcg/kg/dose | intravenous injection, IV | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for geriatric | 288.0 | mg/kg/day | 200 | mcg/kg/minute | intravenous infusion, iv in drop | Brevibloc | esmolol hydrochloride | PDR |
| Max dose for geriatric | 432.0 | mg/kg/day | 300 | mcg/kg/minute | intravenous infusion, iv in drop | Brevibloc | esmolol hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1