Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00181 ...
Drug Name Baclofen
Molecular Weight 213.661
Molecular Formula C10H12ClNO2
CAS Number 1134-47-0
SMILES NCC(CC(O)=O)C1=CC=C(Cl)C=C1
External Links
DRUGBANK DB00181
T3DB T3D2554
PubChem Compound 2284
PDR 1058
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability 0.9 - 0.9 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186984/
Log P 1.3 - 1.3 - http://www.hmdb.ca/metabolites/HMDB0014327
Melting Point 207.0 ℃ 207 ℃ MSDS
pKa 9.62 - 9.62 + 0.1 (amino group) - http://www.labriva.com/monographies/02242151eng.pdf
pKa 3.87 - 3.87 + 0.1 (carboxyl group) - http://www.labriva.com/monographies/02242151eng.pdf

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % ~100 % PO, oral; increasing doses; increasing doses ↓ ; DRUGBANK
Bioavailability 70.0 % >70 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 160.0 ng/ml 160±49 ng/ml Oral single dose; The Pharmacological Basis of Therapeutics
T Max 1.0 h 1.0(0.5-4) h Oral single dose; The Pharmacological Basis of Therapeutics
Metabolic 15.0 % 15 % Liver metabolism; DRUGBANK
Metabolic 85.0 % 85 % Renal metabolism; Urinary excretion; Faeces excretion; DRUGBANK
Clearance 10.8 L/h 180.0 ml/min Total clearance; DRUGBANK
Clearance 6.2 L/h 103.0 ml/min Renal clearance; DRUGBANK
Clearance 0.16 L/h/kg 2.72±0.93 ml/min/kg apparent clearance; Rectal Administration; normal,healthy; Male, men; adults; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.10 L/h/kg 1.7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 59.0 L 59.0 L Apparent volume of distribution; DRUGBANK
Volume of Distribution 0.81 L/kg 0.81±0.12 L/kg Apparent volume of distribution; Rectal Administration; normal,healthy; Male, men; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.65 L/kg 0.65 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 5.5 h ~5.5 h elimination half-life; DRUGBANK
Half-life 3.8 h 3.75±0.96 h normal,healthy; adults; Male, men; The Pharmacological Basis of Therapeutics
Half-life 5.2 h 5.24 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 145.0 mg/kg 145.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 45.0 mg/kg 45.0 mg/kg intravenous injection, IV; mouse; T3DB
Toxicity LD50 78.0 mg/kg 78.0 mg/kg intravenous injection, IV; Rattus, Rat; T3DB
Eliminate Route 75.0 % 70-80 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 69.0 % 69±14 % Urinary excretion; Male, men; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 30.0 % 30 % DRUGBANK
Protein Binding 31.0 % 31±11 % adults; Male, men; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 60.0 mg/day 60 mg/day PO, oral Baclofen baclofen PDR
Max dose for children 40.0 mg/day 40 mg/day PO, oral Baclofen baclofen PDR
Max dose for adolescents 80.0 mg/day 80 mg/day PO, oral Baclofen baclofen PDR
Max dose for adolescents 150.0 mg/day 150 mg/day PO, oral Baclofen baclofen PDR
Max dose for adults 80.0 mg/day 80 mg/day PO, oral Baclofen baclofen PDR
Max dose for adults 150.0 mg/day 150 mg/day PO, oral Baclofen baclofen PDR
Max dose for geriatric 80.0 mg/day 80 mg/day PO, oral Baclofen baclofen PDR
Max dose for geriatric 150.0 mg/day 150 mg/day PO, oral Baclofen baclofen PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1