Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00178 ...
Drug Name Ramipril
Molecular Weight 416.5106
Molecular Formula C23H32N2O5
CAS Number 87333-19-5
SMILES [H][C@@]12CCC[C@]1([H])N([C@@H](C2)C(O)=O)C(=O)[C@H](C)N[C@@H](CCC1=CC=CC=C1)C(=O)OCC
External Links
DRUGBANK DB00178
PubChem Compound 5362129
PDR 282
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.9 - 2.9 - DRUGBANK
Melting Point 109.0 ℃ 109 ℃ PhysProp
Water Solubility 3.5 mg/L 3.5 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 55.0 % 50-60 % PO, oral; DRUGBANK
Bioavailability 28.0 % 28.0 % PO, oral; DRUGBANK
Bioavailability 44.0 % 44.0 % PO, oral; DRUGBANK
Bioavailability 28.0 % 28.0 % PO, oral; The Pharmacological Basis of Therapeutics
Bioavailability 48.0 % 48.0 % PO, oral; Active metabolite; The Pharmacological Basis of Therapeutics
C Max 43.3 ng/ml 43.3±10.2 ng/ml PO, oral; The Pharmacological Basis of Therapeutics
C Max 24.1 ng/ml 24.1±5.6 ng/ml PO, oral; Active metabolite; The Pharmacological Basis of Therapeutics
T Max 1.2 h 1.2±0.3 h PO, oral; The Pharmacological Basis of Therapeutics
T Max 3.0 h 3.0±0.7 h PO, oral; Active metabolite; The Pharmacological Basis of Therapeutics
Metabolic 75.0 % 75.0 % Liver metabolism; Active metabolite; DRUGBANK
Clearance 1.5 L/h/m2 7.2-77.4 ml/min/1.73m2 DRUGBANK
Clearance 4.1 L/h 10.7-126.8 ml/min Renal clearance; normal,healthy; Geriatric; DRUGBANK
Clearance 1.4 L/h/kg 23.0 ml/min/kg PO, oral; intravenous injection, IV; The Pharmacological Basis of Therapeutics
Half-life 3.0 h 2-4 h distribution half-life; DRUGBANK
Half-life 13.5 h 9-18 h elimination half-life; DRUGBANK
Half-life 50.0 h >50 h terminal half-life; DRUGBANK
Half-life 15.0 h 13-17 h DRUGBANK
Half-life 31.5 h 27-36 h DRUGBANK
Half-life 5.0 h 5±2 h RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Half-life 13.5 h 9-18 h elimination half-life; Active metabolite; The Pharmacological Basis of Therapeutics
Half-life 120.0 h ~120 h terminal half-life; The Pharmacological Basis of Therapeutics
Toxicity LD50 10000.0 mg/kg 10.0 g/kg Rattus, Rat; DRUGBANK
Toxicity LD50 10500.0 mg/kg 10.5 g/kg mouse; DRUGBANK
Toxicity LD50 1000.0 mg/kg 1.0 g/kg dog; DRUGBANK
Eliminate Route 60.0 % 60 % Urinary excretion; DRUGBANK
Eliminate Route 40.0 % 40 % Faeces excretion; DRUGBANK
Eliminate Route 2.0 % <2 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 2.0 % <2 % Urinary excretion; PO, oral; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 13.0 % 13±6 % Urinary excretion; PO, oral; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 73.0 % 73 % DRUGBANK
Protein Binding 73.0 % 73±2 % PO, oral; intravenous injection, IV; The Pharmacological Basis of Therapeutics
Protein Binding 56.0 % 56±2 % PO, oral; intravenous injection, IV; Active metabolite; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 6.0 mg/m2/day 6 mg/m2/day PO, oral Altace ramipril PDR
Max dose for adolescents 6.0 mg/m2/day 6 mg/m2/day PO, oral Altace ramipril PDR
Max dose for adults 20.0 mg/day 20 mg/day PO, oral Altace ramipril PDR
Max dose for adults 10.0 mg/day 10 mg/day PO, oral Altace ramipril PDR
Max dose for geriatric 20.0 mg/day 20 mg/day PO, oral Altace ramipril PDR
Max dose for geriatric 10.0 mg/day 10 mg/day PO, oral Altace ramipril PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1