Basic Information
| Drug ID | DDPD00175 |
|
| Drug Name | Pravastatin | |
| Molecular Weight | 424.5277 | |
| Molecular Formula | C23H36O7 | |
| CAS Number | 81093-37-0 | |
| SMILES | [H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC | |
| External Links | ||
| DRUGBANK | DB00175 | |
| PubChem Compound | 54687 | |
| PDR | 3511 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.59 | - | 0.59 | - | 'MSDS' |
| Boiling Point | 600.0 | ℃ | >600 | ℃ | 'MSDS' |
| Melting Point | 172.1 | ℃ | 171.2-173 | ℃ | 'MSDS' |
| Water Solubility | 10000.0 | mg/L | 10 | mg/ml | 'MSDS' |
| pKa | 4.2 | - | 4.2 | - | Dinnekere V. et al. 2016. Scientifica. |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| AUC | 75.0 | ng.h/ml | 60-90 | mcg.h/L | PO, oral; | DRUGBANK | |
| Bioavailability | 17.0 | % | 17.0 | % | PO, oral; | DRUGBANK | Bioavailability | 18.0 | % | 18±8 | % | Oral single dose; | The Pharmacological Basis of Therapeutics |
| C Max | 42.5 | ng/ml | 30-55 | mcg/L | PO, oral; | DRUGBANK | C Max | 33.0 | ng/ml | 28-38 | ng/ml | Oral single dose; | The Pharmacological Basis of Therapeutics |
| T Max | 1.3 | h | 1-1.5 | h | PO, oral; | DRUGBANK | T Max | 1.2 | h | 1-1.4 | h | Oral single dose; | The Pharmacological Basis of Therapeutics |
| Clearance | 0.59 | L/h/kg | 6.3-13.5 | ml/min/kg | adults; | DRUGBANK | Clearance | 450.0 | L/h | 4.0-11 | L/min | Children; | DRUGBANK | Clearance | 0.81 | L/h/kg | 13.5±2.4 | ml/min/kg | Elderly → ;Hepatic cirrhosis, cirr ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ; | The Pharmacological Basis of Therapeutics |
| Volume of Distribution | 0.50 | L/kg | 0.5 | L/kg | DRUGBANK | Volume of Distribution | 0.0340 | L/kg | 31-37 | mL/kg | Steady state volume of distribution; Children; | DRUGBANK | Volume of Distribution | 0.46 | L/kg | 0.46±0.04 | L/kg | The Pharmacological Basis of Therapeutics |
| Half-life | 1.8 | h | 1.8 | h | elimination half-life; | DRUGBANK | Half-life | 0.80 | h | 0.8±0.2 | h | The Pharmacological Basis of Therapeutics | Half-life | 1.8 | h | 1.8±0.8 | h | PO, oral; | RD, renal impairment, Renal disease，including uremia → ;Age → ; | The Pharmacological Basis of Therapeutics |
| Toxicity LD50 | 8939.0 | mg/kg | 8939.0 | mg/kg | PO, oral; mouse; | DRUGBANK | |
| Eliminate Route | 70.0 | % | ~70 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 20.0 | % | ~20 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 47.0 | % | ~47 | % | Urinary excretion; intravenous injection, IV; | DRUGBANK | Eliminate Route | 53.0 | % | 53 | % | Bile excretion; intravenous injection, IV; | DRUGBANK | Eliminate Route | 47.0 | % | 47±7 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 0 | % | ~43-48 | % | plasma proteins; | DRUGBANK | Protein Binding | 45.5 | % | 43-48 | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 20.0 | mg/day | 20 | mg/day | PO, oral | Pravastatin Sodium | pravastatin sodium | PDR |
| Max dose for children | 60.0 | mg/day | 60 | mg/day | PO, oral | Pravastatin Sodium | pravastatin sodium | PDR |
| Max dose for children | 10.0 | mg/day | 10 | mg/day | PO, oral | Pravastatin Sodium | pravastatin sodium | PDR |
| Max dose for children | 60.0 | mg/day | 60 | mg/day | PO, oral | Pravastatin Sodium | pravastatin sodium | PDR |
| Max dose for adolescents | 40.0 | mg/day | 40 | mg/day | PO, oral | Pravastatin Sodium | pravastatin sodium | PDR |
| Max dose for adolescents | 60.0 | mg/day | 60 | mg/day | PO, oral | Pravastatin Sodium | pravastatin sodium | PDR |
| Max dose for adolescents | 20.0 | mg/day | 20 | mg/day | PO, oral | Pravastatin Sodium | pravastatin sodium | PDR |
| Max dose for adolescents | 60.0 | mg/day | 60 | mg/day | PO, oral | Pravastatin Sodium | pravastatin sodium | PDR |
| Max dose for adults | 80.0 | mg/day | 80 | mg/day | PO, oral | Pravastatin Sodium | pravastatin sodium | PDR |
| Max dose for geriatric | 80.0 | mg/day | 80 | mg/day | PO, oral | Pravastatin Sodium | pravastatin sodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1