Basic Information
| Drug ID | DDPD00158 |
|
| Drug Name | Folic acid | |
| Molecular Weight | 441.3975 | |
| Molecular Formula | C19H19N7O6 | |
| CAS Number | 59-30-3 | |
| SMILES | NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1 | |
| External Links | ||
| DRUGBANK | DB00158 | |
| T3DB | T3D2698 | |
| PubChem Compound | 6037 | |
| PDR | 1634 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -2.5 | - | -2.5 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 1.0 | h | 1 | h | PO, oral; | DRUGBANK |
| Clearance | 3.1 | L/h/kg | 52 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 9.7 | L/kg | 9.7 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 2.6 | h | 2.6 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 85.0 | mg/kg | 85.0 | mg/kg | Intraperitoneal, IP; mouse; | DRUGBANK | Toxicity LD50 | 120.0 | mg/kg | 120.0 | mg/kg | intravenous injection, IV; guinea pigs; | DRUGBANK | Toxicity LD50 | 239.0 | mg/kg | 239.0 | mg/kg | intravenous injection, IV; mouse; | DRUGBANK | Toxicity LD50 | 500.0 | mg/kg | 500.0 | mg/kg | intravenous injection, IV; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 410.0 | mg/kg | 410.0 | mg/kg | intravenous injection, IV; rabbit; | DRUGBANK | Toxicity LD50 | 85.0 | mg/kg | 85.0 | mg/kg | Intraperitoneal, IP; mouse; | T3DB | Toxicity LD50 | 120.0 | mg/kg | 120.0 | mg/kg | intravenous injection, IV; guinea pigs; | T3DB | Toxicity LD50 | 239.0 | mg/kg | 239.0 | mg/kg | intravenous injection, IV; mouse; | T3DB | Toxicity LD50 | 500.0 | mg/kg | 500.0 | mg/kg | intravenous injection, IV; Rattus, Rat; | T3DB | Toxicity LD50 | 410.0 | mg/kg | 410.0 | mg/kg | intravenous injection, IV; rabbit; | T3DB |
| Eliminate Route | 50.0 | % | ~50 | % | Urinary excretion; PO, oral; | DRUGBANK | Eliminate Route | 50.0 | % | ~50 | % | Urinary excretion; PO, oral; | DRUGBANK | Eliminate Route | 90.0 | % | ≤90 | % | Urinary excretion; Oral single dose; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 0.6 | mg/day | 0.6 | mg/day | PO, oral | Folic Acid Tablets | folic acid | PDR |
| Max dose for infants | 0.4 | mg/day | 0.4 | mg/day | PO, oral | Folic Acid Tablets | folic acid | PDR |
| Max dose for infants | 0.3 | mg/day | 0.3 | mg/day | PO, oral | Folic Acid Tablets | folic acid | PDR |
| Max dose for children | 0.8 | mg/day | 0.8 | mg/day | PO, oral | Folic Acid Tablets | folic acid | PDR |
| Max dose for adolescents | 1.0 | mg/day | 1 | mg/day | PO, oral | Folic Acid Tablets | folic acid | PDR |
| Max dose for adolescents | 5.0 | mg/day | 5 | mg/day | PO, oral | Folic Acid Tablets | folic acid | PDR |
| Max dose for adolescents | 15.0 | mg/day | 15 | mg/day | PO, oral | Folic Acid Tablets | folic acid | PDR |
| Max dose for elderly | 1.0 | mg/day | 1 | mg/day | PO, oral | Folic Acid Tablets | folic acid | PDR |
| Max dose for elderly | 5.0 | mg/day | 5 | mg/day | PO, oral | Folic Acid Tablets | folic acid | PDR |
| Max dose for elderly | 15.0 | mg/day | 15 | mg/day | PO, oral | Folic Acid Tablets | folic acid | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1