Basic Information
| Drug ID | DDPD00080 |
|
| Drug Name | Daptomycin | |
| Molecular Weight | 1620.693 | |
| Molecular Formula | C72H101N17O26 | |
| CAS Number | 103060-53-3 | |
| SMILES | CCCCCCCCCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](CC(=O)C2=CC=CC=C2N)NC(=O)[C@@H](NC(=O)[C@@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN)NC(=O)CNC1=O)[C@H](C)CC(O)=O | |
| External Links | ||
| DRUGBANK | DB00080 | |
| PubChem Compound | 16134395 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| C Max | 99000.0 | ng/ml | 99±12 | mcg/ml | intravenous infusion, IV in drop; | The Pharmacological Basis of Therapeutics | |
| T Max | 48.0 | h | 48 | h | DRUGBANK | ||
| Clearance | 0.008400 | L/h/kg | 0.14±0.01 | ml/min/kg | RD, renal impairment, Renal disease，including uremia ↓ ; | The Pharmacological Basis of Therapeutics | Clearance | 0.009600 | L/h/kg | 0.16 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.10 | L/kg | 0.1 | L/kg | normal,healthy; adults; | DRUGBANK | Volume of Distribution | 0.0960 | L/kg | 0.096±0.009 | L/kg | RD, renal impairment, Renal disease，including uremia ↑ ; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.0880 | L/kg | 0.088 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 8.5 | h | 8-9 | h | elimination half-life; | DRUGBANK | Half-life | 28.0 | h | 28 | h | elimination half-life; RD, renal impairment, Renal disease，including uremia; | DRUGBANK | Half-life | 7.8 | h | 7.8±1.0 | h | severe renal function ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 8.1 | h | 8.1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 78.0 | % | ~78 | % | Urinary excretion; normal,healthy; | renal insufficiency → ; | DRUGBANK | Eliminate Route | 5.7 | % | 5.7 | % | Faeces excretion; normal,healthy; | DRUGBANK | Eliminate Route | 47.0 | % | 47±12 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 91.5 | % | 90-93 | % | plasma proteins; human, homo sapiens; | DRUGBANK | Protein Binding | 92.0 | % | 92 | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1