Basic Information
| Drug ID | DDPD00014 |
|
| Drug Name | Goserelin | |
| Molecular Weight | 1269.4105 | |
| Molecular Formula | C59H84N18O14 | |
| CAS Number | 65807-02-5 | |
| SMILES | CC(C)C[C@H](NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O | |
| External Links | ||
| DRUGBANK | DB00014 | |
| PubChem Compound | 5311128 | |
| PDR | 1129 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -2.0 | - | -2.0 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 0 | % | 0 | % | PO, oral; | DRUGBANK |
| Bioavailability | 0 | % | 0 | % | PO, oral; | DRUGBANK |
| Clearance | 7.3 | L/h | 121±42.4 | ml/min | DRUGBANK | |
| Volume of Distribution | 44.1 | L | 44.1±13.6 | L | subcutaneous injection, SC; | DRUGBANK |
| Half-life | 4.5 | h | 4-5 | h | DRUGBANK | |
| Eliminate Route | 90.0 | % | >90 | % | Urinary excretion; subcutaneous injection, SC; | DRUGBANK |
| Protein Binding | 27.3 | % | 27.3 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 3.6 | mg | 3.6 | mg | subcutaneous injection, SC | q4w | Zoladex Implant 3.6 mg | goserelin acetate | PDR |
| Max dose for adults | 10.8 | mg | 10.8 | mg | subcutaneous injection, SC; every 3 months | Zoladex Implant 3.6 mg | goserelin acetate | PDR | |
| Max dose for adults | 3.6 | mg | 3.6 | mg | subcutaneous injection, SC | q4w | Zoladex Implant 3.6 mg | goserelin acetate | PDR |
| Max dose for geriatric | 3.6 | mg | 3.6 | mg | subcutaneous injection, SC | q4w | Zoladex Implant 3.6 mg | goserelin acetate | PDR |
| Max dose for geriatric | 10.8 | mg | 10.8 | mg | subcutaneous injection, SC; every 3 months | Zoladex Implant 3.6 mg | goserelin acetate | PDR | |
| Max dose for geriatric | 3.6 | mg | 3.6 | mg | subcutaneous injection, SC | q4w | Zoladex Implant 3.6 mg | goserelin acetate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1