Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00007 ...
Drug Name Leuprolide
Molecular Weight 1209.3983
Molecular Formula C59H84N16O12
CAS Number 53714-56-0
SMILES CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1
External Links
DRUGBANK DB00007
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 152.5 ℃ 150-155 ℃ https://www.trc-canada.com/product-detail/?L330600
pKa 9.6 - 9.6 - http://products.sanofi.ca/en/eligard.pdf

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
C Max 108.3 ng/ml 4.6-212 ng/ml intravenous injection, IV; DRUGBANK
Css 1.1 ng/ml 0.1-2 ng/ml intravenous injection, IV; DRUGBANK
T Max 4.5 h 4-5 h intravenous injection, IV; DRUGBANK
Tss 672.0 h 4 week intravenous injection, IV; DRUGBANK
Clearance 8.0 L/h 7.6-8.3 L/h Average clearance; intravenous injection, IV; normal,healthy; Male, men; DRUGBANK
Clearance 0.12 L/h/kg 2 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 27.0 L 27.0 L Steady state volume of distribution; intravenous injection, IV; normal,healthy; Male, men; DRUGBANK
Volume of Distribution 0.38 L/kg 0.38 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 3.0 h ~3 h elimination half-life; DRUGBANK
Half-life 2.9 h 2.9 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity NOAEL 2000.0 mg/kg/day 2000.0 mg/kg/day intravenous infusion, IV in drop; Rattus, Rat; DRUGBANK
Eliminate Route 5.0 % <5 % Urinary excretion; DRUGBANK
Eliminate Route 5.0 % <5 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 46.0 % 43-49 % plasma proteins; high protein binding; human, homo sapiens; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1