Basic Information
| Drug ID | DDPD00006 |
|
| Drug Name | Bivalirudin | |
| Molecular Weight | 2180.2853 | |
| Molecular Formula | C98H138N24O33 | |
| CAS Number | 128270-60-0 | |
| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(O)=O | |
| External Links | ||
| DRUGBANK | DB00006 | |
| PubChem Compound | 16129704 | |
| PDR | 2143 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.20 | L/h/kg | 3.4 | ml/min/kg | normal,healthy; | DRUGBANK | Clearance | 0.20 | L/h/kg | 3.4 | ml/min/kg | mild renal function; | DRUGBANK | Clearance | 0.16 | L/h/kg | 2.7 | ml/min/kg | moderate renal function; | DRUGBANK | Clearance | 0.17 | L/h/kg | 2.8 | ml/min/kg | severe renal function; | DRUGBANK | Clearance | 0.0600 | L/h/kg | 1.0 | ml/min/kg | DRUGBANK | Clearance | 0.49 | L/h/kg | 8.1 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.20 | L/kg | 0.2 | L/kg | DRUGBANK | Volume of Distribution | 0.27 | L/kg | 0.27 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.42 | h | 25 | min | normal,healthy; | DRUGBANK | Half-life | 0.95 | h | 57.0 | min | severe renal function; | DRUGBANK | Half-life | 3.5 | h | 3.5 | h | DRUGBANK | Half-life | 0.42 | h | 0.42 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 42.0 | mg/kg/day | 1.75 | mg/kg/h | intravenous infusion, iv in drop | Angiomax | bivalirudin | PDR |
| Max dose for geriatric | 42.0 | mg/kg/day | 1.75 | mg/kg/hour | intravenous infusion, iv in drop | Angiomax | bivalirudin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1